abstract：OBJECTIVES:The goal of this study was to evaluate the effect of smoking on the pharmacokinetics and pharmacodynamics (PD) of clopidogrel and prasugrel therapy. BACKGROUND:Major randomized trial data demonstrated that nonsmokers experience less or no benefit from clopidogrel treatment compared with smokers (i.e., the "...

journal_title：Journal of the American College of Cardiology

authors： Gurbel PA,Bliden KP,Logan DK,Kereiakes DJ,Lasseter KC,White A,Angiolillo DJ,Nolin TD,Maa JF,Bailey WL,Jakubowski JA,Ojeh CK,Jeong YH,Tantry US,Baker BA

更新日期：2013-08-06 00:00:00

abstract：OBJECTIVES:This study investigated the determinants and outcomes of acute insertion of a second transcatheter prosthetic valve (TV) within the first (TV-in-TV) or transcatheter valve embolization (TVE) after transcatheter aortic valve replacement (TAVR). BACKGROUND:TAVR failure can occur with both TV-in-TV and TVE as ...

journal_title：Journal of the American College of Cardiology

authors： Makkar RR,Jilaihawi H,Chakravarty T,Fontana GP,Kapadia S,Babaliaros V,Cheng W,Thourani VH,Bavaria J,Svensson L,Kodali S,Shiota T,Siegel R,Tuzcu EM,Xu K,Hahn RT,Herrmann HC,Reisman M,Whisenant B,Lim S,Beohar N,Ma

更新日期：2013-07-30 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine the effect of continuous positive airway pressure (CPAP) therapy on atrial fibrillation (AF) recurrence in patients with obstructive sleep apnea (OSA) undergoing pulmonary vein isolation (PVI). BACKGROUND:OSA is a predictor of AF recurrence following PVI. However, the im...

journal_title：Journal of the American College of Cardiology

authors： Fein AS,Shvilkin A,Shah D,Haffajee CI,Das S,Kumar K,Kramer DB,Zimetbaum PJ,Buxton AE,Josephson ME,Anter E

更新日期：2013-07-23 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effects of bariatric surgery on small artery function and the mechanisms underlying this. BACKGROUND:In lean healthy humans, perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arteries, but this is lost in obesity-associated con...

journal_title：Journal of the American College of Cardiology

authors： Aghamohammadzadeh R,Greenstein AS,Yadav R,Jeziorska M,Hama S,Soltani F,Pemberton PW,Ammori B,Malik RA,Soran H,Heagerty AM

更新日期：2013-07-09 00:00:00

abstract：OBJECTIVES:This study sought to determine the impact of short-term intensive statin therapy on intracoronary plaque lipid content. BACKGROUND:Statin therapy significantly reduces the risk for thrombotic events. Whether or not these benefits are attributable to reduction in plaque lipid content remains to be properly d...

journal_title：Journal of the American College of Cardiology

authors： Kini AS,Baber U,Kovacic JC,Limaye A,Ali ZA,Sweeny J,Maehara A,Mehran R,Dangas G,Mintz GS,Fuster V,Narula J,Sharma SK,Moreno PR

更新日期：2013-07-02 00:00:00

abstract：OBJECTIVES:The goal of this study was to assess mechanisms underlying atrial fibrillation (AF) promotion by exercise training in an animal model. BACKGROUND:High-level exercise training promotes AF, but the underlying mechanisms are unclear. METHODS:AF susceptibility was assessed by programmed stimulation in rats aft...

journal_title：Journal of the American College of Cardiology

authors： Guasch E,Benito B,Qi X,Cifelli C,Naud P,Shi Y,Mighiu A,Tardif JC,Tadevosyan A,Chen Y,Gillis MA,Iwasaki YK,Dobrev D,Mont L,Heximer S,Nattel S

更新日期：2013-07-02 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the efficacy and safety in an "everyday clinical practice" population of anticoagulant-naïve patients with atrial fibrillation (AF) treated with dabigatran etexilate after its post-approval availability in Denmark, compared with warfarin. BACKGROUND:Concerns have been rai...

journal_title：Journal of the American College of Cardiology

authors： Larsen TB,Rasmussen LH,Skjøth F,Due KM,Callréus T,Rosenzweig M,Lip GY

更新日期：2013-06-04 00:00:00

abstract：OBJECTIVES:The study aimed to evaluate inclacumab for the reduction of myocardial damage during a percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation myocardial infarction. BACKGROUND:P-selectin is an adhesion molecule involved in interactions between endothelial cells, platelets, and le...

journal_title：Journal of the American College of Cardiology

authors： Tardif JC,Tanguay JF,Wright SR,Duchatelle V,Petroni T,Grégoire JC,Ibrahim R,Heinonen TM,Robb S,Bertrand OF,Cournoyer D,Johnson D,Mann J,Guertin MC,L'Allier PL

更新日期：2013-05-21 00:00:00

abstract：OBJECTIVES:This study sought to determine the relationship between vascular disease in different arterial territories and advanced age. BACKGROUND:Vascular disease in the peripheral circulation is associated with significant morbidity and mortality. There is little data to assess the prevalence of different phenotypes...

journal_title：Journal of the American College of Cardiology

authors： Savji N,Rockman CB,Skolnick AH,Guo Y,Adelman MA,Riles T,Berger JS

更新日期：2013-04-23 00:00:00

abstract：OBJECTIVES:This study sought to test the hypothesis that colchicine treatment after percutaneous coronary intervention (PCI) can lead to a decrease in in-stent restenosis (ISR). BACKGROUND:ISR rates are particularly high in certain patient subsets, including diabetic patients, especially when a bare-metal stent (BMS) ...

journal_title：Journal of the American College of Cardiology

authors： Deftereos S,Giannopoulos G,Raisakis K,Kossyvakis C,Kaoukis A,Panagopoulou V,Driva M,Hahalis G,Pyrgakis V,Alexopoulos D,Manolis AS,Stefanadis C,Cleman MW

更新日期：2013-04-23 00:00:00

abstract：OBJECTIVES:The study aimed to investigate the difference in major adverse cardiac event (MACE) at 1-year after double kissing (DK) crush versus Culotte stenting for unprotected left main coronary artery (UPLMCA) distal bifurcation lesions. BACKGROUND:DK crush and Culotte stenting were reported to be effective for trea...

journal_title：Journal of the American College of Cardiology

authors： Chen SL,Xu B,Han YL,Sheiban I,Zhang JJ,Ye F,Kwan TW,Paiboon C,Zhou YJ,Lv SZ,Dangas GD,Xu YW,Wen SY,Hong L,Zhang RY,Wang HC,Jiang TM,Wang Y,Chen F,Yuan ZY,Li WM,Leon MB

更新日期：2013-04-09 00:00:00

abstract：:Oxidative stress greatly influences the pathogenesis of various cardiovascular disorders. Coronary interventions, including balloon angioplasty and coronary stent implantation, are associated with increased vascular levels of reactive oxygen species in conjunction with altered endothelial cell and smooth muscle cell f...

journal_title：Journal of the American College of Cardiology

authors： Juni RP,Duckers HJ,Vanhoutte PM,Virmani R,Moens AL

更新日期：2013-04-09 00:00:00

abstract：OBJECTIVES:This study sought to determine the prognostic value of B-type natriuretic peptide (BNP) in patients with heart failure with preserved ejection fraction (HFPEF), in comparison to data in HF patients with reduced left ventricular (LV) EF (≤40%). BACKGROUND:Management of patients with HFPEF is difficult. BNP i...

journal_title：Journal of the American College of Cardiology

authors： van Veldhuisen DJ,Linssen GC,Jaarsma T,van Gilst WH,Hoes AW,Tijssen JG,Paulus WJ,Voors AA,Hillege HL

更新日期：2013-04-09 00:00:00

abstract：OBJECTIVES:This study sought to determine whether epicardial fat volume predicts coronary events in the general population. BACKGROUND:Epicardial adipose tissue (EAT) is suggested to promote plaque development in the coronary artery tree. METHODS:We quantified EAT volume in participants from the prospective populatio...

journal_title：Journal of the American College of Cardiology

authors： Mahabadi AA,Berg MH,Lehmann N,Kälsch H,Bauer M,Kara K,Dragano N,Moebus S,Jöckel KH,Erbel R,Möhlenkamp S

更新日期：2013-04-02 00:00:00

abstract：OBJECTIVES:The study tested whether extreme lipoprotein(a) levels and/or corresponding LPA risk genotypes improve myocardial infarction (MI) and coronary heart disease (CHD) risk prediction beyond conventional risk factors. BACKGROUND:Elevated lipoprotein(a) levels cause MI and CHD. Levels are primarily determined by ...

journal_title：Journal of the American College of Cardiology

authors： Kamstrup PR,Tybjærg-Hansen A,Nordestgaard BG

更新日期：2013-03-19 00:00:00

abstract：OBJECTIVES:This study sought to examine the effect of oral metformin (Mf) therapy on endothelialization in the setting of drug-eluting stents (DES). BACKGROUND:Mf is a commonly used therapy in diabetic patients receiving DES. Mf and locally eluted mammalian target of rapamycin (mTOR) inhibitors used in DES have conver...

journal_title：Journal of the American College of Cardiology

authors： Habib A,Karmali V,Polavarapu R,Akahori H,Nakano M,Yazdani S,Otsuka F,Pachura K,Davis T,Narula J,Kolodgie FD,Virmani R,Finn AV

更新日期：2013-03-05 00:00:00

abstract：:Inappropriate sinus tachycardia (IST) is a syndrome in which the sinus heart rate is inexplicably faster than expected and associated symptoms are present. The heart rate at rest, even in a supine position, can exceed 100 beats/min; minimal activity accelerates the rate rapidly and substantially. Patients with IST may...

journal_title：Journal of the American College of Cardiology

authors： Olshansky B,Sullivan RM

更新日期：2013-02-26 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare outcomes after transfemoral transcatheter aortic valve implantation with the Medtronic CoreValve (MCV) versus the Edwards SAPIEN/SAPIEN XT transcatheter heart valve (ESV) for severe aortic stenosis. BACKGROUND:No large matched comparison study has been conducted so far e...

journal_title：Journal of the American College of Cardiology

authors： Chieffo A,Buchanan GL,Van Mieghem NM,Tchetche D,Dumonteil N,Latib A,van der Boon RM,Vahdat O,Marcheix B,Farah B,Serruys PW,Fajadet J,Carrié D,de Jaegere PP,Colombo A

更新日期：2013-02-26 00:00:00

abstract：OBJECTIVES:This study sought to determine the usefulness of plasma growth differentiation factor 15 (GDF-15) for risk stratification in patients undergoing cardiac surgery in comparison with the additive European System of Cardiac Operative Risk Evaluation (EuroSCORE), N-terminal pro-B-type natriuretic peptide (NTproBN...

journal_title：Journal of the American College of Cardiology

authors： Heringlake M,Charitos EI,Gatz N,Käbler JH,Beilharz A,Holz D,Schön J,Paarmann H,Petersen M,Hanke T

更新日期：2013-02-12 00:00:00

abstract：OBJECTIVES:The purpose of this study was to examine use and describe outcomes of radial access for percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Transradial PCI (TRI) is associated with reduced risk of bleeding and vascular complications, as co...

journal_title：Journal of the American College of Cardiology

authors： Baklanov DV,Kaltenbach LA,Marso SP,Subherwal SS,Feldman DN,Garratt KN,Curtis JP,Messenger JC,Rao SV

更新日期：2013-01-29 00:00:00

abstract：OBJECTIVES:The study sought to determine if left internal thoracic artery (LITA) grafting of the left anterior descending (LAD) at reoperative coronary artery bypass grafting (CABG) improves patient outcomes. BACKGROUND:LITA grafting to the LAD is the gold standard for primary CABG, but its value for reoperative CABG ...

journal_title：Journal of the American College of Cardiology

authors： Sabik JF 3rd,Raza S,Blackstone EH,Houghtaling PL,Lytle BW

更新日期：2013-01-22 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify families affected by early repolarization syndrome (ERS) and to determine the mode of transmission of the disease. BACKGROUND:Early repolarization (ER) has recently been linked to idiopathic ventricular fibrillation. Familial inheritance of the disease has been suggeste...

journal_title：Journal of the American College of Cardiology

authors： Gourraud JB,Le Scouarnec S,Sacher F,Chatel S,Derval N,Portero V,Chavernac P,Sandoval JE,Mabo P,Redon R,Schott JJ,Le Marec H,Haïssaguerre M,Probst V

更新日期：2013-01-15 00:00:00

abstract：OBJECTIVES:This study was undertaken to determine the roles of serum fibrinogen and residual platelet reactivity after clopidogrel pre-treatment on ischemic events after elective percutaneous coronary intervention (PCI). BACKGROUND:Both elevated serum fibrinogen and high platelet reactivity with thienopyridines are as...

journal_title：Journal of the American College of Cardiology

authors： Ang L,Thani KB,Ilapakurti M,Lee MS,Palakodeti V,Mahmud E

更新日期：2013-01-08 00:00:00

abstract：OBJECTIVES:This study sought to evaluate the safety and feasibility of zotarolimus-eluting stent implantation in focal atherosclerotic lesions of the internal pudendal arteries among men with erectile dysfunction (ED) and a suboptimal response to phosphodiesterase-5 inhibitors. BACKGROUND:ED, a common condition, is of...

journal_title：Journal of the American College of Cardiology

authors： Rogers JH,Goldstein I,Kandzari DE,Köhler TS,Stinis CT,Wagner PJ,Popma JJ,Jaff MR,Rocha-Singh KJ

更新日期：2012-12-25 00:00:00

abstract：:The environment in which the field of cardiology finds itself has been rapidly changing. This supplement, an expansion of a report created for the Board of Trustees, is intended to provide a timely snapshot of the socio-economic, political, and scientific aspects of this environment as it applies to practice both in t...

journal_title：Journal of the American College of Cardiology

authors： Laslett LJ,Alagona P Jr,Clark BA 3rd,Drozda JP Jr,Saldivar F,Wilson SR,Poe C,Hart M

更新日期：2012-12-25 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the efficacy of drug-eluting balloons (DEB) compared with paclitaxel-eluting stents (PES) for the reduction of restenosis in small vessels. BACKGROUND:DEB have been shown to be effective in the treatment of coronary in-stent restenosis, but data are limited regarding th...

journal_title：Journal of the American College of Cardiology

authors： Latib A,Colombo A,Castriota F,Micari A,Cremonesi A,De Felice F,Marchese A,Tespili M,Presbitero P,Sgueglia GA,Buffoli F,Tamburino C,Varbella F,Menozzi A

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess whether transradial access for ST-segment elevation acute coronary syndrome undergoing early invasive treatment is associated with better outcome compared with conventional transfemoral access. BACKGROUND:In patients with acute coronary syndrome, bleeding is a signifi...

journal_title：Journal of the American College of Cardiology

authors： Romagnoli E,Biondi-Zoccai G,Sciahbasi A,Politi L,Rigattieri S,Pendenza G,Summaria F,Patrizi R,Borghi A,Di Russo C,Moretti C,Agostoni P,Loschiavo P,Lioy E,Sheiban I,Sangiorgi G

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVES:This study sought to elucidate referral patterns and barriers to adult congenital heart disease (ACHD) care, as perceived by pediatric cardiologists (PCs). BACKGROUND:Management guidelines recommend that care of adults with moderate/complex congenital heart disease be guided by clinicians trained in ACHD. ...

journal_title：Journal of the American College of Cardiology

authors： Fernandes SM,Khairy P,Fishman L,Melvin P,O'Sullivan-Oliveira J,Sawicki GS,Ziniel S,Breitinger P,Williams R,Takahashi M,Landzberg MJ

更新日期：2012-12-11 00:00:00

abstract：OBJECTIVES:The purpose of this study was to characterize long-term outcomes of percutaneous coronary intervention (PCI) in elderly diabetic patients in routine practice. BACKGROUND:Although drug-eluting stent (DES) implantation in diabetic patients is common practice, pivotal randomized trials enrolled <2,500 diabetic...

journal_title：Journal of the American College of Cardiology

authors： Hillegass WB,Patel MR,Klein LW,Gurm HS,Brennan JM,Anstrom KJ,Dai D,Eisenstein EL,Peterson ED,Messenger JC,Douglas PS

更新日期：2012-12-04 00:00:00

abstract：OBJECTIVES:This study sought to characterize temporal trends, patient-specific factors, and geographic variation associated with amputation in patients with lower-extremity peripheral artery disease (LE PAD) during the study period. BACKGROUND:Amputation represents the end-stage failure for those with LE PAD, and litt...

journal_title：Journal of the American College of Cardiology

authors： Jones WS,Patel MR,Dai D,Subherwal S,Stafford J,Calhoun S,Peterson ED

更新日期：2012-11-20 00:00:00

abstract：OBJECTIVES:This study sought to assess the long-term predictive value and net reclassification for risk of cardiovascular disease (CVD) of biomarkers reflecting oxidation-specific epitopes (OSEs). BACKGROUND:OSEs are immunogenic, proinflammatory, and proatherogenic. The long-term predictive value and net reclassificat...

journal_title：Journal of the American College of Cardiology

authors： Tsimikas S,Willeit P,Willeit J,Santer P,Mayr M,Xu Q,Mayr A,Witztum JL,Kiechl S

更新日期：2012-11-20 00:00:00

abstract：OBJECTIVES:This study tested whether genetic variation in the CETP gene is consistent with a protective effect of cholesteryl ester transfer protein (CETP) inhibition on risk of ischemic events and on total mortality, without the adverse effects reported for torcetrapib. BACKGROUND:Torcetrapib, an inhibitor of CETP, i...

journal_title：Journal of the American College of Cardiology

authors： Johannsen TH,Frikke-Schmidt R,Schou J,Nordestgaard BG,Tybjærg-Hansen A

更新日期：2012-11-13 00:00:00

abstract：OBJECTIVES:This study sought to examine patterns of follow-up invasive coronary angiography (ICA) and revascularization (REV) after coronary computed tomography angiography (CCTA). BACKGROUND:CCTA is a noninvasive test that permits direct visualization of the extent and severity of coronary artery disease (CAD). Post-...

journal_title：Journal of the American College of Cardiology

authors： Shaw LJ,Hausleiter J,Achenbach S,Al-Mallah M,Berman DS,Budoff MJ,Cademartiri F,Callister TQ,Chang HJ,Kim YJ,Cheng VY,Chow BJ,Cury RC,Delago AJ,Dunning AL,Feuchtner GM,Hadamitzky M,Karlsberg RP,Kaufmann PA,Leipsic J

更新日期：2012-11-13 00:00:00

abstract：OBJECTIVES:This study determined whether greater volumes of exercise were associated with greater reductions in clinical events. BACKGROUND:The HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial showed that among patients with heart failure (HF), regular exercise confers a ...

journal_title：Journal of the American College of Cardiology

authors： Keteyian SJ,Leifer ES,Houston-Miller N,Kraus WE,Brawner CA,O'Connor CM,Whellan DJ,Cooper LS,Fleg JL,Kitzman DW,Cohen-Solal A,Blumenthal JA,Rendall DS,Piña IL,HF-ACTION Investigators.

更新日期：2012-11-06 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the effect of cardiac resynchronization therapy with a defibrillator (CRT-D) on the risks of first and recurrent ventricular tachyarrhythmic events (VTEs) in the MADIT-CRT. BACKGROUND:Reverse remodeling associated with CRT-D therapy was suggested to reduce arrhythmic risk. Howev...

journal_title：Journal of the American College of Cardiology

authors： Ouellet G,Huang DT,Moss AJ,Hall WJ,Barsheshet A,McNitt S,Klein H,Zareba W,Goldenberg I

更新日期：2012-10-30 00:00:00

abstract：OBJECTIVES:The purpose of the present study was to test the potential of colchicine, an agent with potent anti-inflammatory action, to reduce atrial fibrillation (AF) recurrence after pulmonary vein isolation in patients with paroxysmal AF. BACKGROUND:Proinflammatory processes induced by AF ablation therapy have been ...

journal_title：Journal of the American College of Cardiology

authors： Deftereos S,Giannopoulos G,Kossyvakis C,Efremidis M,Panagopoulou V,Kaoukis A,Raisakis K,Bouras G,Angelidis C,Theodorakis A,Driva M,Doudoumis K,Pyrgakis V,Stefanadis C

更新日期：2012-10-30 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). BACKGROUND:Published findings demonstrate that youth with MetS are at increased risk of cardio-metaboli...

journal_title：Journal of the American College of Cardiology

authors： Magnussen CG,Koskinen J,Juonala M,Chen W,Srinivasan SR,Sabin MA,Thomson R,Schmidt MD,Nguyen QM,Xu JH,Skilton MR,Kähönen M,Laitinen T,Taittonen L,Lehtimäki T,Rönnemaa T,Viikari JS,Berenson GS,Raitakari OT

更新日期：2012-10-23 00:00:00

abstract：:Carotid intima-media thickness (CIMT) measurements have been used in cardiovascular research for more than 2 decades. There is a wealth of evidence showing that CIMT can be assessed in a reproducible manner and that increased CIMT relates to unfavorable risk factor levels and atherosclerosis elsewhere in the arterial ...

journal_title：Journal of the American College of Cardiology

authors： Bots ML,Sutton-Tyrrell K

更新日期：2012-10-23 00:00:00

abstract：OBJECTIVES:This study investigated the effect of a very long-term exercise training program is not known in chronic heart failure (CHF) patients. BACKGROUND:We previously showed that long-term moderate exercise training (ET) improves functional capacity and quality of life in New York Heart Association class II and II...

journal_title：Journal of the American College of Cardiology

authors： Belardinelli R,Georgiou D,Cianci G,Purcaro A

更新日期：2012-10-16 00:00:00

abstract：OBJECTIVES:This study investigated the effect of bariatric surgery (BS)-induced weight loss on cardiac ectopic fat using 3T magnetic resonance imaging in morbid obesity. BACKGROUND:Heart disease is one of the leading causes of mortality and morbidity in obese patients. Deposition of cardiac ectopic fat has been relate...

journal_title：Journal of the American College of Cardiology

authors： Gaborit B,Jacquier A,Kober F,Abdesselam I,Cuisset T,Boullu-Ciocca S,Emungania O,Alessi MC,Clément K,Bernard M,Dutour A

更新日期：2012-10-09 00:00:00